Glucosamine and its cousin Chondroitin are well known for their usefulness in the treatment of arthritis. Most research on these two supplements has focused on their ability to help maintain cartilage. Glucosamine and Chondroitin have properties that also make them powerful anti-inflammatory suppressants in their own right.

Glucosamine and Chondroitin are at the center of a back-and-forth battle between those who are opposed to supporting a supplement that competes with drugs, and those who look to a bevy of studies showing that these supplements slow cartilage degeneration in patients with arthritis. If Glucosamine and Chondroitin also could be shown to be potent anti-inflammatory substances without the horrible cardiac side effects of common NSAID drugs such as Motrin, that would explain why they seem to work so well for many arthritis patients.

It previously has been demonstrated that Glucosamine and Chondroitin in combination therapy pack as powerful an anti-inflammatory punch as the Celebrex. A new double-blinded study published online February 26, 2015, by PLoS One looked solely at blood levels of a common inflammatory marker known as CRP (c-reactive protein) in a small group of overweight patients. Half of these patients received Glucosamine and Chondroitin in combination, and half were given a placebo for four weeks. The groups then crossed over and the half that had been taking Glucosamine and Chondroitin in combination began taking the placebo instead, and vice versa. Results shows that when the patients in each group were taking Glucosamine and Chondroitin in combination, their CRP levels were 23 percent lower, showing a measurable anti-inflammatory effect. Other measurements such as one measuring cell-to-cell signals also were positively impacted by Glucosamine and Chondroitin taken in combination.

Evidence appears to be mounting that Glucosamine and Chondroitin in combination have a potent anti-inflammatory effect outside of the ability of these supplements to protect cartilage. The question patients should ask is why take NSAIDs with nasty side effects when a natural supplement can provide the same benefits with no known side effects?


“Glucosamine/Chondroitin as an Anti-Inflammatory” first appeared as a post on the Regenexx blog.